Nexgenia’s unique technology relies on proprietary stimuli-responsive (SR) polymers that can respond to changes in solution pH, salt concentration, or temperature.  When SR polymers are covalently bound to proteins, synthetic macromolecules, or magnetic particles, they confer the same environmentally-responsive characteristics.  The resulting SR polymer-macromolecule conjugates can quickly and reversibly transition between soluble and aggregated states when the pH, salt concentration or temperature is changed.




Polymer-protein conjugates

SR polymer-protein conjugates are freely soluble and diffusionally unconstrained so they can bind their molecular targets quickly.  The reversible aggregation behavior of SR polymer-protein conjugates allow quick and easy binding and concentration of protein targets for diagnostic and bioprocess applications.


Magnetic nanoparticles

The rapid responsiveness and dual solubility of Nexgenia magnetic nanoparticles (mNP) makes them easy to use and easy to remove from cell suspensions.  Small (0.05 to 0.1 µm diameter) soluble SR polymer-conjugated mNPs do not respond to simple magnetic fields.  However, after a stimulus shift, aggregated SR polymer-conjugated mNPs quickly respond to simple magnet fields.


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